An epitome of DNA repair related genes and mechanisms in thyroid carcinoma
作者: Elisavet GatzidouChristina MichailidiSophia Tseleni-BalafoutaStamatios Theocharis
作者单位: 1Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
2Department of Pathology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
刊名: Cancer Letters, 2009, Vol.290 (2), pp.139-147
来源数据库: Elsevier Journal
DOI: 10.1016/j.canlet.2009.08.007
关键词: Thyroid cancerDNA repair systemsGene polymorphismsCancer predisposition
原始语种摘要: Abstract(#br)Thyroid cancer presents a growing tendency during the last decades, particularly in regions affected by radiation exposure. The present review describes expression alterations and gene polymorphisms of DNA repair related molecules, leading to genomic instability and cell death, being associated with thyroid cancer. The referred variations in DNA repair related genes depict that indirect repair mechanisms are mainly correlated with thyroid gland carcinogenesis. Such abnormalities could participate in thyroid tumor development and progression and could be targeted for future prevention and therapy.
全文获取路径: Elsevier  (合作)
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影响因子:4.258 (2012)

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关键词翻译
关键词翻译
  • carcinoma 癌症
  • repair 修理
  • predisposition 素质
  • thyroid 甲状腺
  • epitome 缩影
  • Cancer 巨蟹座
  • DNA Deoxyribonucleic Acid
  • cancer 癌症
  • related 有关的
  • systems 系统科学与软件