Exosomes in sarcomas: Tiny messengers with broad implications in diagnosis, surveillance, prognosis and treatment
作者: Christos MasaoutisPenelope KorkolopoulouStamatios Theocharis
作者单位: 1First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece
刊名: Cancer Letters, 2019, Vol.449 , pp.172-177
来源数据库: Elsevier Journal
DOI: 10.1016/j.canlet.2019.02.025
关键词: Soft tissue tumorsBiomarkersExtracellular vesiclesLiquid biopsyMiRNA
英文摘要: Abstract(#br)Exosomes are cell-secreted extracellular vesicles, which contain an array of biomolecules, such as proteins, mRNAs, microRNAs, and lipids, take part in intercellular communication and mediate tumor-host interactions. They are increasingly considered as a source of biomarkers for liquid biopsies as well as potential drug vectors. Sarcomas are rare malignant mesenchymal tumours and due to their relative rarity exosomes have not been investigated in as extensively as in epithelial malignancies. Nonetheless, valuable information has been gathered over the last years on the roles of exosomes in sarcomas. In the present review we summarize all relevant data obtained so far from cell lines, animal models and patients with emphasis on their potential clinical utility.
全文获取路径: Elsevier  (合作)
影响因子:4.258 (2012)

  • prognosis 预报
  • surveillance 监视
  • diagnosis 特镇述
  • broad 宽的
  • treatment 处理