Proposal of a morphologic bone marrow response score for imatinib mesylate treatment in chronic myelogenous leukemia
作者: Alessandro LugliMonika EbnoetherSergio B. CogliattiAlois GratwohlJakob PasswegUrs HessWolfgang KorteHanne HawleMarianne TinguelyBettina BorischSara Mach-PascualSilke Von JuergensonnAndré TichelliStephan Dirnhofer
作者单位: 1Institute of Pathology, University Hospital Basel, Basel, Switzerland
2Diagnostic and Therapeutic Hematology, University Hospital Basel, Basel, Switzerland
3Institute of Pathology, Cantonal Hospital St. Gall, St. Gall, Switzerland
4Division of Hematology, Cantonal Hospital St. Gall, St. Gall, Switzerland
5Institute of Pathology, University Hospital of Geneva, Geneva, Switzerland
6Division of Hematology, University Hospital of Geneva, Geneva, Switzerland
7Novartis Pharmaceuticals AG, Oncology, Berne, Switzerland
刊名: Human Pathology, 2004, Vol.36 (1), pp.91-100
来源数据库: Elsevier Journal
DOI: 10.1016/j.humpath.2004.10.012
关键词: Imatinib mesylateChronic myelogenous leukemiaBone marrowResponse criteriaScoring system
原始语种摘要: Summary(#br)Cytogenetic and molecular analyses are essential disease-monitoring parameters in chronic myelogenous leukemia (CML) treated with imatinib. However, a bone marrow morphologic response has not been defined. We reviewed bone marrow histology and cytology of 39 imatinib-treated patients with CML over 49 weeks and introduced a morphologic response score. A significant positive correlation with a complete cytogenetic response was shown for absence of dry tap ( P = .04) and abnormal megakaryocytes ( P < 0.001), normalization of cellularity ( P = .001) and reduction of fibrosis ( P = .01), myelopoiesis:erythropoiesis index ( P = .001), blast ( P = .001) and basophil count ( P < 0.001). The morphologic score integrating these parameters showed an early and late correlation with...
全文获取路径: Elsevier  (合作)
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影响因子:2.843 (2012)

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关键词翻译
关键词翻译
  • myelogenous 骨髓性的
  • leukemia 白血病
  • mesylate 甲磺酸盐
  • morphologic 形态学的
  • response 响应
  • score 得分
  • CML Common Mode Logic
  • chronic 延续很长的
  • myelopoiesis 骨髓形成
  • treated 加工的