Th9 cytokines curb cervical cancer progression and immune evasion
作者: Shilpa Raghuvanshi ChauhanPallavi G. SinghalUpma SharmaKapil BandilKausik ChakrabortyMausumi Bharadwaj
作者单位: 1Division of Molecular Genetics & Biochemistry, ICMR-National Institute of Cancer Prevention and Research, Noida, India
2CSIR-Institute of Genomics and Integrative Biology, Delhi, India
刊名: Human Immunology, 2019, Vol.80 (12), pp.1020-1025
来源数据库: Elsevier Journal
DOI: 10.1016/j.humimm.2019.09.009
关键词: Th9 cellsCervical cancerPU.1 + cellsIL-9IL-21AntitumorTILs
英文摘要: Abstract(#br)Cervical cancer is one of the most common cancers among women in developing countries. Persistent infection with high-risk human papillomavirus (HPV) is the major determinant for the development of cervical cancer. Role of newly discovered T helper 9 (Th9) cells in cervical cancer pathogenesis is yet unfolded. In this study, we observed a huge infiltration of PU.1 + cells and overrepresentation of IL-9R in tissue biopsy specimens of CIN patients in cervical cancer cases. Treatment with Th9 signatory cytokines, IL-9 and IL-21, suppressed proliferation, enhanced apoptosis and stimulated the expression of MHC I and e-cadherin on HeLa cell lines. Th9 thus seems enhance antitumor immune response through T cell cytotoxicity and play crucial role in a controlling malignant cell...
全文获取路径: Elsevier  (合作)
影响因子:2.298 (2012)

  • cytokines 细胞浆移动
  • immune 免疫的
  • evasion 规避
  • cervical 颈的
  • cells 麻风细胞
  • cancer 癌症
  • progression 级数