Lobular neoplasia and invasive lobular breast cancer: Inter-observer agreement for histological grading and subclassification
作者: Nora SchaumannMieke RaapLaura HinzeLuisa RiegerChristian M. SchürchWiebke AntonopoulosStefanie AvrilTill KrechMaximilian DämmrichGian KayserFlorian PulsFlorian LängerMarianne TinguelyHans KreipeMatthias Christgen
作者单位: 1Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
2Institute of Pathology, University of Bern, Murtenstr. 31, 3008 Bern, Switzerland
3Department of Pathology, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, 10900 Euclid Ave., Cleveland, OH 44106-7288, USA
4Institute of Pathology, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany
5Gemeinschaftspraxis für Pathologie, Alte Bahnhofstr. 1, 97422 Schweinfurt, Germany
6Institute of Surgical Pathology, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 115a, 79106 Freiburg, Germany
7Department of Pathology and Genetics, University of Gothenburg, Gula Stråket 8, 413 46 Göteborg, Sweden
8Institute of Pathology Enge, Hardturmstrasse 133, 8005 Zürich, Switzerland
刊名: Pathology - Research and Practice, 2019, Vol.215 (11)
来源数据库: Elsevier Journal
DOI: 10.1016/j.prp.2019.152611
关键词: Lobular neoplasiaInvasive lobular breast cancerInter-observer agreementKi67Mammary gland
原始语种摘要: Abstract(#br)Lobular neoplasia (LN), invasive lobular breast cancer (ILBC) and related pleomorphic variants represent a distinct group of neoplastic mammary gland lesions. This study assessed the inter-observer agreement of histological grading in a series of ILBC and LN.(#br)54 cases (36x ILBC, 18x LN) were evaluated by 17 observers. 3978 classification calls on various histological features, including nuclear grade, proliferative activity (Ki67 immunohistochemistry, categorical scoring), histological grade and pleomorphism were obtained. Pairwise Cohen’s kappa values were calculated and compared between various features and different observer subsets with variable histomorphological experience.(#br)In ILBC, pairwise inter-observer agreement for histological grade ranged from poor to...
全文获取路径: Elsevier  (合作)
影响因子:1.213 (2012)

  • lobular 小裂片状的
  • neoplasia 新生物形成
  • grading 粒级成层
  • histological 组织的
  • agreement 协议
  • breast 胸部
  • observer 测候员
  • invasive 侵入的
  • grade 品位
  • gland