In vitro radiation-induced apoptosis and early response to low-dose radiotherapy in non-Hodgkin's lymphomas
作者: Bernard DubrayChristel BretonJozo DelicJerzy KlijanienkoZofia MaciorowskiPhilippe VielhAlain FourquetJanine DumontHenri MagdelenatJean-Marc Cosset
作者单位: 1Département d'Oncologie Radiothérapie, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France
2Laboratoire de Radiopathologie, Laboratoire de Recherche Correspondant N° 21 du C.E.A. (DRR Fontenay aux Roses), Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France
3Unité de Cytopathologie et de Cytométrie Clinique, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France
4Service d'Hématologie, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France
刊名: Radiotherapy and Oncology, 1998, Vol.46 (2), pp.185-191
来源数据库: Elsevier Journal
DOI: 10.1016/S0167-8140(97)00148-5
关键词: ApoptosisNon-Hodgkin's lymphomaLow-dose radiotherapyPredictive assay
原始语种摘要: Abstract(#br)Purpose : Prospective investigation of spontaneous and in vitro radiation-induced apoptosis to predict early response to palliative radiotherapy in patients with non-Hodgkin's lymphomas.(#br)Patients and methods : Fine-needle sampling was performed in 28 tumor sites (26 patients) and yielded adequate cell numbers in 27 cases. Apoptotic cells were counted by fluorescence microscopy immediately after sampling and after 24-h culture (spontaneous apoptosis) and 24 h after 2- and 10-Gy in vitro irradiation (radiation-induced apoptosis). Early response to low-dose in vivo radiotherapy (mostly 4 Gy in two fractions over 3 days) was evaluated 15 days after treatment.(#br)Results : The tumor response rates at 15 days were 11 (39%) complete responses, nine (32%) responses of greater...
全文获取路径: Elsevier  (合作)
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影响因子:4.52 (2012)

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关键词翻译
关键词翻译
  • radiotherapy 放射线疗法
  • radiation 辐射
  • induced 感应的
  • response 响应
  • apoptosis 细胞死
  • vitro 体外
  • lymphoma 淋巴瘤
  • predictive 预言
  • spontaneous 自发的
  • early