TGF-βRIl, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 alterations are not associated with microsatellite instability or p53 mutations in invasive urothelial carcinoma of the urinary bladder
作者: Angelica A. SaettaPenelope KorkolopoulouMaria KarlouGeorgia LevidouAthina GoudopoulouIrene ThymaraAngeliki StamatelliMichalis TzivrasNikolaos V. MichalopoulosEuphemia Thomas-TsagliEfstratios Patsouris
作者单位: 1Department of Pathology, Medical School, National and Kapodistrian University of Athens, Greece
刊名: Pathology, 2007, Vol.39 (4), pp.425-432
来源数据库: Elsevier Journal
DOI: 10.1080/00313020701444457
关键词: BAXhMSH3hMSH6IGFIIRTGF-βiRIIurothelial carcinomaMSI
英文摘要: Summary(#br)Aim(#br)The aim of this study was to determine the potential synchronous contribution of alterations in TGF-βiRII, BAX, IGFIIR, caspase-5, hMSH3 and hMSH6 genes to the development and clinical outcome of bladder cancer, in relation to p53 mutations, microsatellite status and hMLHI/ hMSH2 expression.(#br)Methods(#br)Molecular biology techniques as well as immuno- histochemistry were applied in 69 samples from patients with urothelial carcinoma.(#br)Results(#br)Microsatellite alterations were observed in TGF- βRII(A) 10 (16%) and BAX(G) 8 (3%), irrespective of the presence of p53 mutations, but not in IGFIIR(G) 8 , caspase- 5(A) 10 , hMSH3(A) 8 and hMSH6(C) 8 . A statistically significant correlation could be found only between hMLH1 expression and the presence of microsatellite...
全文获取路径: Elsevier  (合作)
影响因子:2.657 (2012)

  • TGF 转化生长因子
  • bladder 膀胱
  • carcinoma 癌症
  • urinary 尿的
  • invasive 侵入的
  • instability 不稳定性
  • associated 相关的