Clusterin expression in medullary thyroid carcinoma is inversely correlated with the presence of lymph node metastases
作者: Najat MourraMalika BennisPierre-Yves BoelleBeatrix Cochand-PriolletMarine LefevreCharles LepineAndre BalatonJerzy KlijanienkoFabrice MenegauxFrederique Tissier
作者单位: 1Department of Pathology, St-Antoine Hospital, AP-HP, 75012 Paris, France
2Department of Surgery, St-Antoine Hospital, AP-HP, 75012 Paris, France
3Department of Biostatic and Public Health, St-Antoine Hospital, AP-HP, 75012 Paris, France
4Pathology Department, Cochin Hospital, AP-HP, 75014 Paris, France
5Pathology Department, Tenon Hospital, AP-HP, 75020 Paris, France
6Pathology Department, Bievre Laboratory, and St-Joseph Hospital, 75014 Paris, France
7Pathology Department, Curie Institut, 75005 Paris, France
8Department of General and Endocrine Surgery, Pitie-Salpetriere Hospital, AP-HP, UPMC, 75013 Paris, France
9Pathology Department, Pitie-Salpetriere Hospital, AP-HP, UPMC, 75013 Paris, France
刊名: Human Pathology, 2017, Vol.64 , pp.37-43
来源数据库: Elsevier Journal
DOI: 10.1016/j.humpath.2017.03.009
关键词: ClusterinMedullary thyroid carcinomaThyroid tumorsNeuroendocrine tumorsImmunohistochemistryEndocrine tumors
英文摘要: Summary(#br)Clusterin (CLU) is a sulfated glycoprotein implicated in many physiological and pathological processes, including tumorigenesis. Several studies have reported the overexpression of CLU in human neoplasm, examined by immunohistochemistry. However, there are no extensive data on its role in the thyroid. Here we investigate CLU expression in thyroid tumors, and the potential correlation between this expression and clinicopathological parameters. Immunohistochemistry with anti-CLU was performed on paraffin sections from 39 thyroid tumors. Only medullary thyroid carcinomas (MTCs) were positive (n = 5). To confirm these results, 130 further cases (including 4 C-cell hyperplasia), their matched lymph node metastases (46 cases), and lymph node recurrences (10 cases) were analyzed. All...
全文获取路径: Elsevier  (合作)
影响因子:2.843 (2012)

  • carcinoma 癌症
  • medullary 脊髓的
  • correlated 相关
  • thyroid 甲状腺
  • lymph 淋巴
  • inversely 相反地
  • metastases 移位变化
  • expression 表示
  • presence 存在