The impact of very high initial PSA on oncological outcomes after radical prostatectomy for clinically localized prostate cancer
作者: Derya TilkiPhilipp MandelPierre I. KarakiewiczAlexander HeinzeHartwig HulandMarkus GraefenSophie Knipper
作者单位: 1Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany
2Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
3Department of Urology, University Hospital Frankfurt, Frankfurt, Germany
4Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada
刊名: Urologic Oncology: Seminars and Original Investigations, 2020, Vol.38 (5), pp.379-385
来源数据库: Elsevier Journal
DOI: 10.1016/j.urolonc.2019.12.027
关键词: Biochemical recurrenceMetastatic progressionCancer-specific mortalityProstate-specific antigen level
原始语种摘要: Abstract(#br)Background(#br)To analyze oncological outcomes of very high-risk patients with initial PSA 50-99.9 and ≥100 ng/ml who underwent radical prostatectomy (RP) for clinically localized prostate cancer.(#br)Methods(#br)Overall, 2,811 RP patients (1992-2018) with negative preoperative CT-scan and bone scintigraphy were included. The impact of preoperative PSA level, categorized as 20-49.9 ( n = 2,195) vs. 50-99.9 ( n = 454) vs. ≥100 ng/ml ( n = 162) on biochemical recurrence (BCR)-free survival, metastasis-free survival (MFS) and cancer-specific survival (CSS) was assessed using Kaplan-Meier and multivariable Cox regression models.(#br)Results(#br)Median follow-up was 47.5 months. Ten-year BCR-free survival rates were 46.9 vs. 32.1 vs. 29.0% within PSA-categories 20-49.9 vs. 50-99.9...
全文获取路径: Elsevier  (合作)

  • PSA 被保护的存储器地址
  • prostatectomy 前列腺切除术
  • localized 修]定位[域
  • clinically 临床上
  • radical 
  • preoperative 操作前的
  • survival 生存
  • recurrence 循环
  • cancer 癌症
  • initial 开首字母