Correlation between pharmacokinetic/pharmacodynamic indices and clinical outcomes in Japanese patients with skin and soft tissue infections treated with daptomycin: analysis of a phase III study
作者: Yoshio TakesueHiroshige MikamoShinya KusachiShinichi WatanabeKenichi TakahashiTomoko YoshinariMikio IshiiNaoki Aikawa
作者单位: 1Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan
2Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan
3Department of Surgery, Toho University Medical Center Ohashi Hospital, Tokyo, Japan
4Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
5Japan Development, MSD K.K., Tokyo, Japan
6Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan
刊名: Diagnostic Microbiology & Infectious Disease, 2015, Vol.83 (1), pp.77-81
来源数据库: Elsevier Journal
DOI: 10.1016/j.diagmicrobio.2015.05.013
关键词: DaptomycinMethicillin-resistant Staphylococcus aureusPharmacokineticsSkin and soft tissue infectionCreatine phosphokinase
原始语种摘要: Abstract(#br)The relationships between pharmacokinetic (PK)/pharmacodynamic (PD) indices and outcomes were investigated in patients with skin and soft tissue infection (SSTI) who received daptomycin at 4mg/kg/day. Efficacy was evaluated in 55 patients from whom Staphylococcus aureus was isolated, with success rates of 94.5% and 69.1% for clinical and microbiological responses, respectively. The odds ratio for the relationship between the area under the day 1 concentration–time curve (AUC 0–24h ) to the MIC and the probability of clinical success was 1.03 (95% confidence interval [CI] 0.73–1.45), and that for the relationship for probability of microbiological success was 0.94 (95% CI 0.81–1.09). In 82 patients in the safety analysis, only 1 met the...
全文获取路径: Elsevier  (合作)

  • clinical 临床的
  • tissue 组织
  • Japanese 日本人日语日本的
  • between 在中间
  • resistant 耐久的
  • analysis 分析
  • relationship 关系
  • phosphokinase 磷酸激素
  • concentration 浓度
  • infection 感染