Brain changes in children and adolescents with obsessive–compulsive disorder before and after treatment: A voxel-based morphometric MRI study
作者: Luisa LázaroNuria BargallóJosefina Castro-FornielesCarles FalcónSusana AndrésRosa CalvoCarme Junqué
作者单位: 1Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain
2Image Diagnostic Center, Hospital Clínic, Barcelona, Spain
3IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain
4Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain
刊名: Psychiatry Research: Neuroimaging, 2008, Vol.172 (2), pp.140-146
来源数据库: Elsevier Journal
DOI: 10.1016/j.pscychresns.2008.12.007
关键词: Obsessive–compulsive disorderChildren and adolescentsTreatment naïveNeuroimagingStatistical parametric mapping
原始语种摘要: Abstract(#br)The aim of this study is to determine whether children and adolescents with treatment-naïve obsessive–compulsive disorder (OCD) present brain structure differences in comparison with healthy subjects, and to evaluate brain changes after treatment and clinical improvement. Initial and 6 months' follow-up evaluations were performed in 15 children and adolescents (age range=9–17 years, mean=13.7, S.D.=2.5; 8 male, 7 female) with DSM-IV OCD and 15 healthy subjects matched for age, sex and estimated intellectual level. An evaluation with psychopathological scales and magnetic resonance imaging (MRI) was carried out at admission and after 6 months' follow-up. Axial...
全文获取路径: Elsevier  (合作)
影响因子:3.364 (2012)

  • compulsive 强制的
  • disorder 无序
  • treatment 处理
  • children 子女
  • voxel 体元
  • parietal 顶骨
  • improvement 改良
  • statistically 统计地
  • present 出席的
  • right 右边的