Outcomes in highly sensitized pediatric heart transplant patients using current management strategies
作者: Alfred Asante-KorangErnest K. AmankwahMayra Lopez-CeperoJeremy RingewaldJennifer CarapellucciDiane KrasnoperoAlex BergJames QuintessenzaJeffrey P. Jacobs
作者单位: 1Divisions of Pediatric Cardiology
2Clinical and Translational Research Organization, All Children’s Hospital/Johns Hopkins Medicine, St Petersburg, Florida
3Lifelink Immunology Lab, Tampa, Florida
4Division of Cardiac Surgery, All Children’s Hospital/Johns Hopkins University, St Petersburg, Florida
刊名: Journal of Heart and Lung Transplantation, 2015, Vol.34 (2), pp.175-181
来源数据库: Elsevier Journal
DOI: 10.1016/j.healun.2014.09.027
关键词: pediatrichearttransplantsensitizationantibodieshuman leukocyte antigen
原始语种摘要: Background(#br)Previous studies have suggested that children with pre-formed anti-HLA antibodies (PRA) undergoing orthotopic heart transplantation (OHT) have increased risk for rejection, coronary artery vasculopathy (CAV) and death. In 2005, our program started utilizing aggressive desensitization (including plasmapheresis, IVIg, pulse cytoxan and rituximab) with the goal of improving outcomes for these patients. The purpose of this study was to compare outcomes with this new strategy in recipients with pre-OHT high PRA (>10%) vs low PRA ≤10%).(#br)Methods(#br)A retrospective study of 70 consecutive pediatric OHT patients was undertaken between January 2005 and July 2013 to identify patients with pre-OHT PRA >10% (high PRA), or PRA ≤10% (low PRA). Demographic/data information and...
全文获取路径: Elsevier  (合作)
影响因子:5.112 (2012)

  • PRA Packet Routing Address
  • sensitized 敏化的
  • transplant 移植体
  • pediatric 儿科的
  • rejection 抑制
  • heart 心脏
  • aggressive 侵蚀的
  • orthotopic 常位的
  • significant 有效的
  • survival 生存