Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy
作者: Tarique HussainBie TanGhulam MurtazaGang LiuNajma RahuMuhammad Saleem KalhoroDildar Hussain KalhoroTolulope O AdebowaleMuhammad Usman MazharZia ur RehmanYordan MartínezShahzad Akber KhanYulong Yin
作者单位: 1College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, Hunan, China
2Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China
3Animal Sciences Division, Nuclear Institute for Agriculture and Biology (NIAB), P. O. Box: 128, Jhang Road, Faisalabad, 38000, Pakistan
4Shaheed Benazir Bhutto University of Veterinary & Animal Sciences, Sakrand, 67210, Sindh, Pakistan
5Department of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh, 70050, Pakistan
6Food Engineering and Bioprocess Technology, Asian Institute of Technology, Bangkok, 12120, Thailand
7Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Educ
刊名: Pharmacological Research, 2020, Vol.152
来源数据库: Elsevier Journal
DOI: 10.1016/j.phrs.2020.104629
关键词: T2DMOxidative stressInflammation and flavonoids
原始语种摘要: Abstract(#br)Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction of free radicals where oxidative stress could contribute it. Possible factors are defective insulin signals, glucose oxidation, and degradation of glycated proteins as well as alteration in glutathione metabolism which induced hyperglycemia. Previous studies revealed a link between T2DM with oxidative stress, inflammation and insulin resistance which are assumed to be regulated by numerous cellular networks such as NF-κB, PI3K/Akt, MAPK, GSK3 and PPARγ. Flavonoids are ubiquitously present in the nature and classified according to their chemical structures for example, flavonols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones. Flavonoids indicate poor bioavailability...
全文获取路径: Elsevier  (合作)
影响因子:4.346 (2012)

  • therapeutic 治疗的
  • efficacy 效验
  • enhance 增强
  • delivery 移交
  • diabetes 糖尿病
  • diabetic 糖尿病患者
  • glucose 葡萄糖
  • flavonoids 黄酮类似物
  • their 他们的
  • oxidative 氧化的