Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders
作者: Ahmad Al-SaffarShota TakemiHiwa K. SaaedIchiro SakataTakafumi Sakai
作者单位: 1Department of Medical Sciences, Gastroeneterology & Hepatology, Uppsala University Hospital, 751 85, Uppsala, Sweden
2Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama, 338-8570, Japan
3Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaymaniyah, Iraq
4Area of Life-NanoBio, Division of Strategy Research, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama, 338-8570, Japan
刊名: Best Practice & Research Clinical Gastroenterology, 2019, Vol.40-41
来源数据库: Elsevier Journal
DOI: 10.1016/j.bpg.2019.101633
关键词: Gastrointestinal motilityFunctional gastrointestinal disordersAnimal model
英文摘要: Abstract(#br)Alteration in the gastrointestinal (GI) motility and transit comprises an important component of the functional gastrointestinal disorders (FGID). Available animal GI motility and transit models are to study symptoms (delayed gastric emptying, constipation, diarrhea) rather than biological markers to develop an effective treatment that targets the underlying mechanism of altered GI motility in patients. Animal data generated from commonly used methods in human like scintigraphy, breath test and wireless motility capsule may directly translate to the clinic. However, species differences in the control mechanism or pharmacological responses of GI motility may compromise the predictive and translational value of the preclinical data to human. In this review we aim to provide a...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • animal 动物的
  • motility 游动性
  • transit 渡越
  • functional 功能的