|作者：||Susana Andrés, Teresa Boget, Luisa Lázaro, Rafael Penadés, Astrid Morer, Manel Salamero, Josefina Castro-Fornieles|
1Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic of Barcelona, Barcelona, Spain
2Department of Clinical Psychology, Hospital Clinic of Barcelona, Barcelona, Spain
3Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
|刊名：||Biological Psychiatry, 2006, Vol.61 (8), pp.946-951|
|关键词：||Adolescents; children; executive functions; memory; neuropsychological tests; obsessive-compulsive disorder;|
|原始语种摘要：||Background(#br)Several studies have found impairment in visual memory and visual organization in adults with obsessive-compulsive disorder (OCD), but little is known about the neuropsychological profile of children and adolescents with this disorder. The influence of clinical variables such as age, severity of obsessive-compulsive symptomatology, depressive symptomatology, and pharmacological treatment on cognitive performance in these patients has not been thoroughly studied.(#br)Methods(#br)A neuropsychological battery designed for this study was administered to 35 patients with DSM-IV-TR diagnosis of OCD without psychiatric comorbidity aged between 7 and 18 years and 35 gender- and age-matched healthy subjects.(#br)Results(#br)Children and adolescents with OCD performed significantly... worse on verbal and visual memory and velocity. When depressive symptomatology was controlled, impairment in visual memory, visual organization, and velocity again was found, but impairment in verbal memory was not. Neuropsychological impairment was not related to age, obsessive-compulsive severity, and pharmacological treatment.(#br)Conclusions(#br)Children and adolescents with OCD without psychiatric comorbidity with acute illness show impairment in visual memory, visual organization, and velocity, similar to adults. The influence of depressive symptomatology is important in cognitive performance. No relation was found between neuropsychology and age, severity of obsessive-compulsive symptomatology, or pharmacological treatment in this study.|