Localisation of p2x 2 receptor subunit immunoreactivity on nitric oxide synthase expressing neurones in the brain stem and hypothalamus of the rat: a fluorescence immunohistochemical study
作者: S.T YaoA.V GourineK.M SpyerJ.A BardenA.J Lawrence
作者单位: 1Department of Pharmacology, Monash University, P.O. Box 13E, Clayton, Victoria 3800, Australia
2Department of Physiology, Royal Free and University College London Medical School, Rowland Hill Street, London NW3 2PF, UK
3Institute of Biomedical Research, University of Sydney, Sydney, New South Wales 2006, Australia
刊名: Neuroscience, 2003, Vol.121 (2), pp.411-419
来源数据库: Elsevier Journal
DOI: 10.1016/S0306-4522(03)00435-4
关键词: P2-purinoceptorsventrolateral medullaparaventricular nucleusmedulla oblongataautonomic nervous system
原始语种摘要: Abstract(#br)A large body of evidence suggests that nitric oxide (NO) and ATP act as neurotransmitters in the regulatory mechanisms concerning several autonomic functions at the level of both the hypothalamus and the brain stem. In the present study, we investigated whether neuronal NO synthase containing neurones also express P2X 2 receptor subunit of the ATP-gated ion channel via double-labelling fluorescence immunohistochemistry. Our data demonstrate that a high percentage of neuronal NO synthase-immunoreactive neurones are also P2X 2 -immunoreactive in the rostral ventrolateral medulla (98%) and supraoptic nucleus of the hypothalamus (92%). Significant numbers of neuronal NO synthase-immunoreactive neurones are also P2X 2 -immunoreactive in the subpostremal (48%) and commissural (65%)...
全文获取路径: Elsevier  (合作)
影响因子:3.122 (2012)

  • hypothalamus 丘脑下部
  • subunit 亚单位
  • synthase 合酶
  • receptor 接受体
  • expressing 压榨
  • nitric 氮的
  • nucleus 晶核
  • autonomic 自发的
  • neuronal 二乙基溴乙酰胺
  • immunoreactive 免疫活性的