Occupancy of adenosine A 2A receptors by istradefylline in patients with Parkinson's disease using 11 C-preladenant PET
作者: Kenji IshibashiYoshiharu MiuraKei WagatsumaJun ToyoharaKiichi IshiwataKenji Ishii
作者单位: 1Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
2Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
3Institute of Cyclotron and Drug Discovery Research, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan
4Department of Biofunctional Imaging, Fukushima Medical University, Fukushima, Japan
刊名: Neuropharmacology, 2018, Vol.143 , pp.106-112
来源数据库: Elsevier Journal
DOI: 10.1016/j.neuropharm.2018.09.036
关键词: Adenosine A 2A receptorIstradefyllineParkinson's diseasePET11 C-preladenant
原始语种摘要: Abstract(#br)Istradefylline, an adenosine A 2A receptor (A 2A R) antagonist, is effective as an adjunct to levodopa and can alleviate “off” time and motor symptoms in patients with Parkinson's disease (PD). The present study aimed to calculate occupancy rates of A 2A Rs by administrating istradefylline 20 mg or 40 mg, which is the currently approved dose for PD in Japan. Additionally, A 2A R availability was compared between patients with PD and healthy controls. Ten patients with PD under levodopa therapy and six age-matched healthy controls were included. The patients underwent a total of two 11 C-preladenant positron emission tomography scans before and after the administration of istradefylline 20 mg or 40 mg (both n = 5). Binding potential (BP ND ) was calculated to estimate A 2A R...
全文获取路径: Elsevier  (合作)
影响因子:4.114 (2012)

  • adenosine 腺苷
  • PET PagE frame Table
  • disease