Evidence for the involvement of purinergic signalling in the control of respiration
作者: T ThomasV RalevicM BardiniG BurnstockK.M Spyer
作者单位: 1Autonomic Neuroscience Institute, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
2Department of Physiology, Division of Medical Sciences, University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK
3School of Biomedical Sciences, The University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
刊名: Neuroscience, 2001, Vol.107 (3), pp.481-490
来源数据库: Elsevier Journal
DOI: 10.1016/S0306-4522(01)00363-3
关键词: ATPP2 receptorsimmunohistochemistryventrolateral medullabrainstembreathing
原始语种摘要: Abstract(#br)The ventrolateral medulla has a critical role in the generation and patterning of respiration via an extensive network of respiratory neurones. We have investigated the effects of activating purinergic P2 receptors within the ventrolateral medulla of the anaesthetised rat on the overall pattern of respiratory activity. In addition, using immunohistochemical techniques, we have identified the subtypes of P2X receptors in the ventrolateral medulla. Unilateral microinjection of ATP into the ventrolateral medulla reduced in a dose-dependent manner, or abolished, resting phrenic nerve discharge recorded as an indication of central inspiratory drive. ATP also elicited increases in blood pressure and variable changes in heart rate. These effects were mimicked by microinjection of...
全文获取路径: Elsevier  (合作)
影响因子:3.122 (2012)

  • ventrolateral 腹侧的
  • respiration 呼吸
  • microinjection 显微注射
  • medulla 骨髓
  • receptor 接受体
  • brainstem 脑干
  • suramin 苏拉明
  • respiratory 呼吸过程
  • involvement 财政困难
  • blocked 分块