Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice
作者: Xavier GallegoJessica Ruiz-MedinaOlga ValverdeSusanna MolasNoemí RoblesJosefa SabriàJohn C. CrabbeMara Dierssen
作者单位: 1Genes and Disease Program, Center for Genomic Regulation (CRG), UPF, Barcelona, Spain
2CIBER de Enfermedades Raras (CIBERER), CRG-UPF, Barcelona, Spain
3Neurobiology of Behavior Research Group, Department of Health and Life Experimental Sciences, Pompeu Fabra University (UPF), Barcelona, Spain
4Department of Biochemistry, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès, Barcelona, Spain
5Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, VA Medical Center, Portland, OR 97239, USA
刊名: Alcohol, 2012, Vol.46 (3), pp.205-215
来源数据库: Elsevier Journal
DOI: 10.1016/j.alcohol.2011.11.005
关键词: NicotineEthanolTransgenic micenAChR subunitsPreference drinkingDependence
英文摘要: Abstract(#br)Abuse of alcohol and smoking are extensively co-morbid. Some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nAChRs). We tested mice with transgenic over expression of the alpha 5, alpha 3, beta 4 receptor subunit genes, which lie in a cluster on human chromosome 15, that were previously shown to have increased nicotine self-administration, for several responses to ethanol. Transgenic and wild-type mice did not differ in sensitivity to several acute behavioral responses to ethanol. However, transgenic mice drank less ethanol than wild-type in a two-bottle (ethanol vs. water) preference test. These results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as...
全文获取路径: Elsevier  (合作)
影响因子:2.255 (2012)

  • subunit 亚单位
  • expression 表示
  • receptor 接受体
  • ethanol 乙醇
  • intake 收气
  • nicotinic 烟碱酸的
  • over 在上方