Involvement of prolyl isomerase PIN1 in the cell cycle progression and proliferation of hepatic oval cells
作者: Prabodh RisalNirajan ShresthaLokendra ChandKarl G. SylvesterYeon Jun Jeong
作者单位: 1Laboratory of Liver Regeneration, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Geuman-dong, Duckjin-gu, Jeonju, 561-712, South Korea
2Department of Biochemistry, School of Medical Sciences, Kathmandu University, Dhulikhel, Kavre, Nepal
3Department of Surgery, Division of Pediatric Surgery, Stanford University School of Medicine, PSRL, 257 Campus Drive, Stanford, CA 94305-5148, USA
4Department of Surgery, Chonbuk National University Medical School, 634-18 Geuman-dong, Duckjin-gu, Jeonju, 516-712, South Korea
刊名: Pathology - Research and Practice, 2017, Vol.213 (4), pp.373-380
来源数据库: Elsevier Journal
DOI: 10.1016/j.prp.2017.01.005
关键词: 35-Diethoxycarbonyl-14-DihydrocollidineHepatic progenitor cellsLiver injuryOval cellsPeptidyl-prolyl isomerase Pin1
原始语种摘要: Abstract(#br)Liver regenerates remarkably after toxic injury or surgical resection. In the case of failure of resident hepatocytes to restore loss, repopulation is carried out by induction, proliferation, and differentiation of the progenitor cell. Although, some signaling pathways have been verified to contribute oval cell-mediated liver regeneration, role of Peptidyl-prolyl cis -trans isomerase NIMA-interacting 1(Pin1) in the oval cells proliferation is unknown. In the present study, we evaluate the role of Pin1 in oval cells proliferation. In our study, the expression of Pin1 in the mice liver increased after three weeks feeding of 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) diet along with the proliferation of oval cells. The expression of Pin1 was higher in oval cells compared...
全文获取路径: Elsevier  (合作)
影响因子:1.213 (2012)

  • isomerase 异构酶
  • cells 麻风细胞
  • expression 表示
  • prolyl 脯氨酰基
  • increased 增加
  • proliferation 增生
  • knockdown 击倒
  • interacting 相克的
  • numbers 数目
  • treated 加工的