Distinct amyloid precursor protein processing machineries of the olfactory system
作者: Jae Yeon KimAmeer RasheedSeung-Jun YooSo Yeun KimBongki ChoGowoon SonSeong-Woon YuKeun-A. ChangYoo-Hun SuhCheil Moon
作者单位: 1Department of Brain and Cognitive Sciences, Graduate School, Daegu Gyeungbuk Institute of Science and Technology, Daegu, Republic of Korea
2Convergence Research Advanced Centre for Olfaction, Daegu Gyeungbuk Institute of Science and Technology, Daegu, Republic of Korea
3Department of Pharmacology, School of Medicine, Gachon Medical School, Incheon, Republic of Korea
刊名: Biochemical and Biophysical Research Communications, 2018, Vol.495 (1), pp.533-538
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2017.10.153
关键词: Alzheimer's disease(AD)Amyloid precursor protein(APP)Olfactory systemOlfactory epithelium(OE)Γ-SecretasePresenilin
英文摘要: Abstract(#br)Processing of amyloid precursor protein (APP) occurs through sequential cleavages first by β-secretase and then by the γ-secretase complex. However, abnormal processing of APP leads to excessive production of β-amyloid (Aβ) in the central nervous system (CNS), an event which is regarded as a primary cause of Alzheimer's disease (AD). In particular, gene mutations of the γ-secretase complex—which contains presenilin 1 or 2 as the catalytic core—could trigger marked Aβ accumulation.(#br)Olfactory dysfunction usually occurs before the onset of typical AD-related symptoms (eg, memory loss or muscle retardation), suggesting that the olfactory system may be one of the most vulnerable regions to AD. To date however, little is known about why the olfactory system is affected so early...
全文获取路径: Elsevier  (合作)

  • olfactory 嗅觉的
  • protein 蛋白质
  • amyloid 淀粉状朊
  • precursor 前驱物质
  • system 
  • processing 加工