Astrocytic expression of the CXCL12 receptor, CXCR7/ACKR3 is a hallmark of the diseased, but not developing CNS
作者: Malte PuchertFabian PelknerGregor SteinDoychin N. AngelovJohannes BoltzeDaniel-Christoph WagnerFrancesca OdoardiAlexander FlügelWolfgang J. StreitJürgen Engele
作者单位: 1Institute of Anatomy, University of Leipzig, Liebigstr. 13, 04103 Leipzig, Germany
2Cologne University Hospital, Department of Orthopedic and Trauma Surgery, Uniklinik Köln, 50924 Köln, Germany
3Institute of Anatomy 1, University of Cologne, Joseph-Stelzmann-Str. 9, 50924 Köln, Germany
4Department of Medical Cell Technology, Fraunhofer Research Institution for Marine Biotechnology and Institute of Medical and Marine Biotechnology, University of Lübeck, Mönkhofer Weg 239a, 23562 Lübeck, Germany
5Institute of Pathology, Building 706, Langenbeckstr. 1, 55131 Mainz, Germany
6Institute for Multiple Sclerosis Research, Department of Neuroimmunology, University Medical Centre Göttingen, Waldweg 33, 37073 Göttingen, Germany
7Department of Neuroscience, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, USA
刊名: Molecular and Cellular Neuroscience, 2017, Vol.85 , pp.105-118
来源数据库: Elsevier Journal
DOI: 10.1016/j.mcn.2017.09.001
关键词: CXCR7CXCR4AstrocytesGlia limitansMCAOEAESpinal cord compressionCerebral infarctionAlzheimer's disease
英文摘要: Abstract(#br)Based on our previous demonstration of CXCR7 as the major mediator of CXCL12 signaling in cultured astrocytes, we have now compared astrocytic expression of the CXCL12 receptors, CXCR7 and CXCR4, during CNS development and disease. In addition, we asked whether disease-associated conditions/factors affect expression of CXCL12 receptors in astrocytes. In the late embryonic rat brain, CXCR7 + /GFAP + cells were restricted to the ventricular/subventricular zone while CXCR4 was widely absent from GFAP-positive cells. In the early postnatal and adult brain, CXCR7 and CXCR4 were almost exclusively expressed by GFAP-immunoreactive astrocytes forming the superficial glia limitans. Contrasting the situation in the intact CNS, a striking increase in astrocytic CXCR7 expression was...
全文获取路径: Elsevier  (合作)
影响因子:3.837 (2012)

  • developing 显影
  • diseased 患病的
  • receptor 接受体
  • expression 表示
  • infarction 梗塞
  • compression 压缩
  • hallmark 检验印记
  • CNS Communications Network Simulator