Linear correlation between rheological, mechanical and mucoadhesive properties of polycarbophil polymer blends for biomedical applications
作者: Sabrina Barbosa De Souza FerreiraJéssica Bassi Da SilvaFernanda Belincanta Borghi-PangoniMariana Volpato JunqueiraMarcos Luciano Bruschi
作者单位: 1Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná, Brazil
2Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil
刊名: Journal of the Mechanical Behavior of Biomedical Materials, 2017, Vol.68 , pp.265-275
来源数据库: Elsevier Journal
DOI: 10.1016/j.jmbbm.2017.02.016
关键词: MucoadhesionPolycarbophilFlow propertiesViscoelasticityLinear correlation calculationPoloxamer 407
原始语种摘要: Abstract(#br)Polycarbophil is widely used in a variety of pharmaceutical formulations, mainly for their strong ability to adhere to the epithelial and mucous barriers (bio/mucoadhesion). On the other hand, its association with the thermoresponsive polymer (poloxamer 407) has been poorly explored. This work investigates the rheological, mechanical and mucoadhesive properties of polymer blends containing polycarbophil and poloxamer 407, in order to select the best formulations for biomedical and pharmaceutical applications. Mechanical (hardness, compressibility, adhesiveness, softness, and mucoadhesion) and rheological characteristics (consistency index, yield value and hysteresis area) showed that 20% (w/w) poloxamer 407- polymer blends exhibited higher values parameters. However, the...
全文获取路径: Elsevier  (合作)

  • rheological 流变学的
  • polymer 聚合物
  • biomedical 生物医学
  • mechanical 机械的
  • polycarbophil 聚卡波非
  • interaction 相互酌
  • properties 道具
  • poloxamer 泊洛沙姆
  • applications 应用程序
  • systems 系统科学与软件