Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway
作者: Yung-Ho HsuYen-Cheng ChenYu-Wei ChenTzu-Hsuan ChiuYung-Ting KuoCheng-Hsien Chen
作者单位: 1Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan
2Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan
3Division of Nephrology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taiwan
4Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taiwan
5Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taiwan
刊名: Metabolism, 2020, Vol.104
来源数据库: Elsevier Journal
DOI: 10.1016/j.metabol.2020.154143
关键词: Far-infraredDiabetesΒ-cellsInsulinMitochondrial function
英文摘要: Abstract(#br)Insulin deficiency in type 2 diabetes mellitus (DM) involves a decline in both pancreatic β-cell mass and function. Enhancing β-cell preservation represents an important therapeutic strategy to treat type 2 DM. Far-infrared (FIR) radiation has been found to induce promyelocytic leukemia zinc finger protein (PLZF) activation to protect the vascular endothelium in diabetic mice. The influence of FIR on β-cell preservation is unknown. Our previous study reveals that the biologically effective wavelength of FIR is 8–10 μm. In the present study, we investigated the biological effects of FIR (8–10 μm) on both survival and insulin secretion function of β-cells. FIR reduced pancreatic islets loss and increased insulin secretion in nicotinamide-streptozotocin-induced DM mice, but only...
全文获取路径: Elsevier  (合作)
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影响因子:3.096 (2012)

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关键词翻译
关键词翻译
  • diabetic 糖尿病患者
  • mitochondria 线粒体
  • radiation 辐射
  • infrared 红外线
  • decline 推辞
  • pathway 轨道
  • function 函数
  • cells 麻风细胞