Exceptional release kinetics and cytotoxic selectivity of oxidised MWCNTs double-functionalised with doxorubicin and prostate-homing peptide
作者: Vedran MilosavljevicLudmila KrejcovaRoman GuranHana BuchtelovaDorota WawrzakLukas RichteraZbynek HegerPavel KopelVojtech Adam
作者单位: 1Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic
2Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic
3Institute of Chemistry, Environmental Protection and Biotechnology, Jan Dlugosz University of Czestochowa, Armii Krajowej 13/15, PL-42-201 Czestochowa, Poland
刊名: Colloids and Surfaces B: Biointerfaces, 2017, Vol.156 , pp.123-132
来源数据库: Elsevier Journal
DOI: 10.1016/j.colsurfb.2017.05.008
关键词: Carbon nanomaterialProstate-homing peptideDrug deliveryNanomedicine
原始语种摘要: Abstract(#br)Multiwall carbon nanotubes (MWCNTs) are among the frequently studied carbon materials, particularly because of their physical and chemical properties and high potential for application in materials chemistry, industry, and medicine. MWCNTs are very promising as transporters of bioactive molecules because of their π electrons and large surface area, which can be easily modified, mostly by the application of inorganic acids for the introduction of carboxylic moieties on the surface. In the present study, we designed an oxidised MWCNTs ( o MWCNTs) transporter for the targeted delivery of doxorubicin (Dox). The modification of o MWCNTs with prostate-homing peptide (SMSIARL) promotes increased cytotoxicity for prostate cancer cells. Using advanced analytical techniques, we studied...
全文获取路径: Elsevier  (合作)
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影响因子:3.554 (2012)

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关键词翻译
关键词翻译
  • kinetics 动力学
  • double 双重的
  • prostate 前列腺
  • homing 自动导引
  • cytotoxic 细胞毒素的
  • studied 学习
  • introduction 导言
  • promising 前提
  • doxorubicin 阿霉素
  • chemical 化学的