Eicosapentaenoic acid abolishes inhibition of insulin-induced mTOR phosphorylation by LPS via PTP1B downregulation in skeletal muscle
作者: Hong-Kui WeiZhao DengShu-Zhong JiangTong-Xing SongYuan-Fei ZhouJian PengYa-Xiong Tao
作者单位: 1Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, 430070, Wuhan, PR China
2Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, USA
刊名: Molecular and Cellular Endocrinology, 2017, Vol.439 , pp.116-125
来源数据库: Elsevier Journal
DOI: 10.1016/j.mce.2016.10.029
关键词: Eicosapentaenoic acidLipopolysaccharideMyotubesInsulinMammalian target of rapamycin
英文摘要: Abstract(#br)Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) increase insulin signaling in skeletal muscle. In the current study, we investigated the effect of eicosapentaenoic acid (EPA) on insulin-induced mammalian target of rapamycin (mTOR) phosphorylation in myotubes. We showed that EPA did not affect basal and insulin-induced mTOR phosphorylation in myotubes. However, EPA abolished lipopolysaccharide (LPS) -induced deficiency in insulin signaling ( P < 0.05). Pre-incubation of nuclear factor κB (NF-κΒ) and c-Jun N-terminal kinases (JNK) inhibitors prevented the decreased insulin-induced mTOR phosphorylation elicited by LPS ( P < 0.05). In addition, in protein tyrosine phosphatase-1B (PTP1B) knockdown myotubes, LPS failed to decrease insulin-induced mammalian target of rapamycin...
全文获取路径: Elsevier  (合作)
影响因子:4.039 (2012)

  • induced 感应的
  • insulin 胰岛素
  • inhibition 抑制
  • muscle 肌肉
  • LPS Laboratory Peripheral System
  • skeletal 骨架
  • PTP 点到点控制