Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol)
作者: Luciano AdoriniGiuseppe PennaSusana AmuchasteguiChiara CossettiFrancesca AquilanoRoberto MarianiBenedetta FibbiAnnamaria MorelliMilan UskokovicEnrico ColliMario Maggi
作者单位: 1BioXell, 20132 Milan, Italy
2Andrology Unit, University of Florence, 50139 Florence, Italy
3BioXell Inc., 07110 Nutley, NJ, USA
刊名: Journal of Steroid Biochemistry and Molecular Biology, 2007, Vol.103 (3-5), pp.689-693
来源数据库: Elsevier Journal
DOI: 10.1016/j.jsbmb.2006.12.065
关键词: Benign prostatic hyperplasiaChronic prostatitis/chronic pelvic pain syndromeVitamin D analogs
原始语种摘要: Abstract(#br)The prostate is a target organ of vitamin D receptor (VDR) agonists and represents an extra-renal site of 1,25-dihydroxyvitamin D 3 synthesis, but its capacity to respond to VDR agonists has, so far, been almost exclusively probed for the treatment of prostate cancer. We have analyzed the capacity of VDR agonists to treat benign prostatic hyperplasia (BPH), a complex syndrome characterized by a static component related to prostate overgrowth, a dynamic one responsible for urinary irritative symptoms, and an inflammatory component. Preclinical data demonstrate that VDR agonists, and notably BXL-628 (elocalcitol), reduce the static component of BPH by inhibiting the activity of intra-prostatic growth factors downstream of the androgen receptor, and the dynamic component by...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • prostate 前列腺
  • prostatic 前列腺的
  • vitamin 维生素
  • receptor 接受体
  • irritative 发怒的
  • inflammation 炎症
  • growth 生长
  • hyperplasia 增生
  • androgen 雄激素
  • prostatitis 前列腺炎