Imaging of in vitro parenteral drug precipitation
作者: Daniel C. EvansMichael W. KudenovKimberly C. SassenrathEustace L. DereniakSamuel H. Yalkowsky
作者单位: 1College of Pharmacy, University of Arizona, 1295 N. Martin PO Box 210202 Tucson, AZ 85721, United States
2College of Optical Sciences, The University of Arizona, 1630 E. University Blvd., P.O. Box 210094, Tucson, AZ 85721-0094, United States
刊名: International Journal of Pharmaceutics, 2016, Vol.512 (1), pp.219-223
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2016.08.030
原始语种摘要: Abstract(#br)Solid particulate matter introduced into the bloodstream as a result of parenteral drug administration can produce serious pathological conditions. Particulate matter that cannot be eliminated by pre-infusion filtration is often the result of drug precipitation that occurs when certain parenteral formulations are mixed with blood. A new device is designed to model the mixing of drug formulations with flowing blood utilizing a uniquely designed flow cell and a CCD camera to view the formulation as it is mixed with a blood surrogate in real time. The performance of the proposed device is measured using 3 commercially available parenteral formulations previously tested using a validated in vitro model.
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • parenteral 不经肠的
  • blood 血液
  • precipitation 沉淀
  • pathological 病理学的
  • formulation 配方
  • previously 以前
  • administration 管理
  • device 装置
  • filtration 过滤
  • particulate 粒子