Comparison of pathological complete response rates after neoadjuvant short-course radiotherapy or chemoradiation followed by delayed surgery in locally advanced rectal cancer
作者: Sieske HoendervangersAlice M. CouwenbergMartijn P.W. IntvenWilhelmina M.U. van GrevensteinHelena M. Verkooijen
作者单位: 1Department of Radiotherapy, University Medical Center Utrecht, The Netherlands
2Department of Surgery, University Medical Center Utrecht, The Netherlands
3Imaging Division, University Medical Center Utrecht, The Netherlands
刊名: European Journal of Surgical Oncology, 2018, Vol.44 (7), pp.1013-1017
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejso.2018.03.014
关键词: Locally advanced rectal cancerShort course radiotherapyChemoradiationPathological complete response
英文摘要: Abstract(#br)Introduction(#br)Patients with locally advanced rectal cancer (LARC) who are unfit for chemoradiation (CRT), are often offered short-course radiotherapy followed by delayed surgery (SCRT-delay). This entails a lower radiation dose, no chemotherapy and a shorter treatment period. This may lower their chances for complete tumor response and, as such, organ-sparing approaches. The purpose of this study was to compare the pathological complete response (pCR) rates between neoadjuvant CRT and SCRT-delay in patients with LARC in a nationwide database from the Netherlands.(#br)Methods(#br)In the population based Netherlands Cancer Registry, clinical stage III rectal cancer patients, diagnosed between 2008 and 2014, who underwent CRT or SCTR-delay were selected. pCR (ypT0N0), near...
全文获取路径: Elsevier  (合作)
影响因子:2.614 (2012)

  • pathological 病理学的
  • rectal 直肠的
  • radiotherapy 放射线疗法
  • course 航向
  • cancer 癌症
  • locally 局部地
  • delayed 延迟的
  • advanced 先进的
  • complete 实行
  • response 响应