High homogeneity of MMR deficiency in ovarian cancer
作者: Christoph FrauneJanina RosebrockRonald SimonClaudia Hube-MaggGeorgia Makrypidi-FrauneMartina KluthFranziska BüscheckDoris HöflmayerBarbara SchmalfeldtVolkmar MüllerLinn WölberIsabell WitzelPeter PaluchowskiChristian WilkeUwe HeilenkötterIngo von LeffernTill Sebastian ClauditzWaldemar WilczakGuido SauterStefan SteurerEike Burandt
作者单位: 1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany
2Department of Gynecology, University Medical Center Hamburg-Eppendorf, Germany
3Department of Gynecology, Regio Clinic Pinneberg, Pinneberg, Germany
4Department of Gynecology, Regio Clinic Elmshorn, Elmshorn, Germany
5Department of Gynecology, Regio Clinic and Senior Citizen Center Itzehoe, Itzehoe, Germany
6Department of Gynecology, Albertinen Clinic, Hamburg, Germany
刊名: Gynecologic Oncology, 2020, Vol.156 (3), pp.669-675
来源数据库: Elsevier Journal
DOI: 10.1016/j.ygyno.2019.12.031
关键词: Intratumoral heterogeneityMicrosatellite instability MSIMismatch repair deficiency dMMROvarian cancerTissue microarray
英文摘要: Abstract(#br)Objective(#br)Mismatch repair (MMR) deficiency and Bethesda panel microsatellite instability (MSI) are increasingly analyzed to identify tumors that might benefit from immune checkpoint inhibitors, but tumor heterogeneity is a potential obstacle for such analyses. In ovarian cancer, data on intratumoral heterogeneity of MMR deficiency/MSI are lacking.(#br)Methods(#br)N = 582 ovarian cancers were screened for MMR deficiency by immunohistochemistry (IHC) on a tissue microarray. 10 cases suspect for MMR deficiency were identified among 478 interpretable cancers and repeated IHC on large sections combined with polymerase chain reaction (PCR)-based MSI analysis validated MMR deficiency/MSI in 9 of these tumors.(#br)Results(#br)MMR deficiency/MSI was predominantly seen in...
全文获取路径: Elsevier  (合作)
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影响因子:3.929 (2012)

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关键词翻译
关键词翻译
  • ovarian 卵巢的
  • deficiency 不足
  • heterogeneity 不均匀性
  • instability 不稳定性
  • homogeneity 均匀性
  • cancer 癌症
  • repair 修理