Vanillin derivative VND3207 activates DNA-PKcs conferring protection against radiation-induced intestinal epithelial cells injury in vitro and in vivo
作者: Ming LiYue LangMeng-Meng GuJianming ShiBenjamin P.C. ChenLan YuPing-Kun ZhouZeng-Fu Shang
作者单位: 1State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
2Suzhou Digestive Diseases and Nutrition Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215008, China
3Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China
4Department of Radiation Oncology, University of Texas Southwestern Medical Center, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
5Department of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
刊名: Toxicology and Applied Pharmacology, 2020, Vol.387
来源数据库: Elsevier Journal
DOI: 10.1016/j.taap.2019.114855
关键词: VND3207Radiation-induced intestinal injuriesDNA-PKcsDNA damageMitotic catastrophe
英文摘要: Abstract(#br)Vanillin is a natural compound endowed with antioxidant and anti-mutagenic properties. We previously identified the vanillin derivative VND3207 with strong radio-protective and antioxidant effects and found that VND3207 confers survival benefit and protection against radiation-induced intestinal injury (RIII) in mice. We also observed that VND3207 treatment enhanced the expression level of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) in human lymphoblastoid cells with or without γ-irradiation. DNA-PKcs is a critical component of DNA double strand break repair pathway and also regulates mitotic progression by stabilizing spindle formation and preventing mitotic catastrophe in response to DNA damage. In the present study, we found that VND3207 protected...
全文获取路径: Elsevier  (合作)
影响因子:3.975 (2012)

  • induced 感应的
  • intestinal 肠的
  • against 反对
  • derivative 衍生物
  • epithelial 上皮的
  • catastrophe 灾变
  • radiation 辐射
  • cells 麻风细胞
  • DNA Deoxyribonucleic Acid
  • injury 损害