8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival
作者: Till EichenauerDavid C. BannenbergMartina KluthCorinna WittmerFranziska BüscheckKatharina MöllerDavid DumChristoph FrauneClaudia Hube-MaggChristina Möller-KoopRoland DahlemMargit FischMichael RinkSilke RiechardtMaria Christina TsourlakisChristian BernreutherSarah MinnerRonald SimonGuido SauterWaldemar WilczakTill S. Clauditz
作者单位: 1Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
刊名: Urologic Oncology: Seminars and Original Investigations, 2020, Vol.38 (2), pp.43.e13-43.e20
来源数据库: Elsevier Journal
DOI: 10.1016/j.urolonc.2019.09.024
关键词: Renal cell cancer8p21 deletionFluorescence in situ hybridizationTissue microarrayPrognosis
原始语种摘要: Abstract(#br)Background and methods(#br)8p deletions are common in renal cell carcinoma. To study their prognostic impact and association with kidney cancer phenotype, a tissue microarray with 1,809 cancers was analyzed by fluorescence in situ hybridization for 8p21 copy numbers.(#br)Results(#br)One thousand four hundred and seventy four interpretable tumors showed substantial differences between renal cancer subtypes. That 8p deletion was only seen in 1 (0.5%) of 216 papillary carcinomas underscores the biologic uniqueness of papillary kidney cancer, which is also defined by a highly distinct morphology. 8p deletions were found in 13.2% of 976 clear cell carcinomas, 7.8% of 77 chromophobe carcinomas, 0.8% of 119 oncocytomas, but also in several rare tumor entities including 1 of 4...
全文获取路径: Elsevier  (合作)

  • carcinoma 癌症
  • survival 生存
  • unfavorable 不利
  • renal 肾的
  • chromophobe 难染的
  • associated 相关的
  • papillary 乳头的
  • multilocular 多室的
  • tumor 肿胀
  • malignancy 恶性