Analysis of Molecular Recognition Features (MoRFs) in membrane proteins
作者: Ioly Kotta-LoizouGeorgios N. TsaousisStavros J. Hamodrakas
作者单位: 1Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15701, Greece
刊名: BBA - Proteins and Proteomics, 2013, Vol.1834 (4), pp.798-807
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbapap.2013.01.006
关键词: MoRFsIntrinsic disorderProtein–protein interactionsTransmembrane proteinsPeripheral membrane proteins
原始语种摘要: Abstract(#br)Molecular Recognition Features (MoRFs) are defined as short, intrinsically disordered regions in proteins that undergo disorder-to-order transition upon binding to their partners. As their name suggests, they are implicated in molecular recognition, which serves as the initial step for protein–protein interactions. Membrane proteins constitute approximately 30% of fully sequenced proteomes and are responsible for a wide variety of cellular functions. The aim of the current study was to identify and analyze MoRFs in membrane proteins. Two datasets of MoRFs, transmembrane and peripheral membrane protein MoRFs, were constructed from the Protein Data Bank, and sequence, structural and functional analysis was performed. Characterization of our datasets revealed their unique...
全文获取路径: Elsevier  (合作)

  • protein 蛋白质
  • membrane 
  • disorder 无序
  • Recognition 识别
  • their 他们的
  • responsible 负责的
  • functional 功能的
  • focused 聚焦的
  • structural 构造
  • associating 缔合