Exploring the Galleria mellonella model to study antifungal photodynamic therapy
作者: Lívia Mara Alves Figueiredo-GodoiRaquel Telles MenezesJéssica Shiotani CarvalhoMaíra Terra GarciaAguinaldo Garcez SegundoAntonio Olavo Cardoso JorgeJuliana Campos Junqueira
作者单位: 1Department of Biosciences and Oral Diagnosis, São Paulo State University (Unesp), Institute of Science and Technology (ICT), São José dos Campos Campus, São Paulo, Brazil
2São Leopoldo Mandic Dental Research Center, Campinas, Brazil
刊名: Photodiagnosis and Photodynamic Therapy, 2019, Vol.27 , pp.66-73
来源数据库: Elsevier Journal
DOI: 10.1016/j.pdpdt.2019.05.010
关键词: Candida albicansInvertebratePhotodynamic therapyAntimicrobial photodynamic Therapy
原始语种摘要: Abstract(#br)Background(#br)Antimicrobial photodynamic therapy (aPDT) shows antimicrobial activity on yeast of the genus Candida . In aPDT, the depth at which the light penetrates the tissue is extremely important for the elaboration of the treatment. The aim of this study was to evaluate the action of aPDT on experimental candidiasis and the laser impact in the tissue using Galleria mellonella as the infection model.(#br)Methods(#br)G. mellonella larvae were infected with different Candida albicans strains. After 30 min, they were treated with methylene blue-mediated aPDT and a low intensity laser (660 nm). The larvae were incubated at 37 °C for seven days and monitored daily to determine the survival curve, using the Log-rank test (Mantel Cox). To evaluate the distribution of the laser...
全文获取路径: Elsevier  (合作)
影响因子:2.243 (2012)