Chiral toxicity of muscone to embryonic zebrafish heart
作者: Ming LiLiang YaoHao ChenXuan NiYao XuWengjing DongMingliang FangDa ChenAowulijiLiang XuBaoquan ZhaoJiang DengKevin WH. KwokJingfeng YangWu Dong
作者单位: 1Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicant and Toxicology, Collage of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia 028000, China
2National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China
3Function Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture, Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
4School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore
5School of Environment, Guangdong Key Laboratory of Environment Pollution and Health, Jinan University, Guangzhou, Guangdong 510632, China
6College of Traditional Mongolian Medicine and Pharmacy, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China
7College of Chemistry and Chemical Engineering, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, China
8State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
9Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi Guizhou563000, China
10Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong
刊名: Aquatic Toxicology, 2020, Vol.222
来源数据库: Elsevier Journal
DOI: 10.1016/j.aquatox.2020.105451
关键词: MusconeZebrafish embryoCardiotoxicityAtrial/Ventricular myosin heavy ChainChirality
原始语种摘要: Abstract(#br)Musk compounds are often used as to treat heart-related diseases and are widely used in Asia. Muscone is one of the most important physiologically active compounds of natural musk. Muscone is a chiral compound and can be further classified into S-muscone and R-muscone and both are present in synthetic musk. While these two chiral isomers have significant differences in odor properties, their difference in toxicity is still unknown. This study used zebrafish as an animal model to compare cardiac toxicities of S-muscone and R-muscone. Results showed that both compounds were acutely toxic to zebrafish embryos causing mortality, decreased hatching rate, pericardial edema, and decreased heart beat rate. These toxicities were modulated through increased Myh6 and Myh7 mRNA...
全文获取路径: Elsevier  (合作)
影响因子:3.73 (2012)

  • muscone 香酮
  • toxicity 毒性
  • chiral 手性的
  • heart 心脏
  • isomers 等比值线
  • synthetic 合成的
  • mRNA m核糖核酸
  • concentration 浓度
  • compound 复合物
  • classified 保密的