Decreased cerebrospinal fluid levels of neutral and basic amino acids in patients with Parkinson's disease
作者: José Antonio MolinaFélix Javier Jiménez-JiménezPilar GómezCarmela VargasJosé Antonio NavarroMiguel Ortı́-ParejaTeresa GasallaJulián Benito-LeónFélix BermejoJoaquı́n Arenas
作者单位: 1Departments of Neurology, Hospital Doce de Octubre, Madrid, Spain
2Department of Neurology, Hospital Universitario `Prı́ncipe de Asturias', Alcalá de Henares, Madrid, Spain
3Department of Biochemistry, Hospital Doce de Octubre, Madrid, Spain
刊名: Journal of the Neurological Sciences, 1997, Vol.150 (2), pp.123-127
来源数据库: Elsevier Journal
DOI: 10.1016/S0022-510X(97)00069-5
关键词: Parkinson's diseaseBasic amino acidsNeutral amino acidsCerebrospinal fluidPlasma
原始语种摘要: Abstract(#br)We measured the CSF levels of 21, and the plasma levels of 26, amino acids in 31 patients with Parkinson's disease (PD) and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had lower CSF levels of taurine, alanine, valine, leucine, isoleucine, ethanolamine, citrulline, ornithine, lysine, histidine, arginine, and alpha-aminobutyric acid. PD patients not treated with levodopa or with dopamine agonists had higher CSF tyrosine and phenylalanine levels than those not treated with these drugs and also than controls. PD patients had higher plasma levels of phosphoserine, threonine, methionine, tyrosine, sarcosine and α-aminoadipic acid, and lower plasma levels of valine, leucine, and tryptophan, than controls. The...
全文获取路径: Elsevier  (合作)
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影响因子:2.243 (2012)

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关键词翻译
关键词翻译
  • amino 氨基
  • phenylalanine 苯丙氨酸
  • fluid 
  • neutral 中性的
  • controls 控制机构
  • ethanolamine 乙醇胺
  • valine 缬氨酸
  • citrulline 瓜氨酸
  • levodopa 左旋多巴
  • isoleucine 异白氨酸