Effectiveness of olanzapine monotherapy and olanzapine combination treatment in the long term following acute mania — Results of a two year observational study in bipolar disorder (EMBLEM)
作者: Ana Gonzalez-PintoEduard VietaCatherine ReedDiego NovickAlessandra BarracoJaume AguadoJosep Maria Haro
作者单位: 1International Mood Disorders Research Centre, Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Hospital Santiago Apóstol, University of the Basque Country, Vitoria, Spain
2Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain
3Lilly Research Centre, Windlesham, UK
4Medical Department, Eli Lilly Italia, Sesto Fiorentino, Italy
5Sant Joan De Deu-SSM, Fundació Sant Joan de Déu, CIBERSAM, Barcelona, Spain
刊名: Journal of Affective Disorders, 2011, Vol.131 (1-3), pp.320-329
来源数据库: Elsevier Journal
DOI: 10.1016/j.jad.2010.11.037
关键词: Bipolar disorderCombination therapyMaintenance therapyMonotherapyOlanzapineProspective observational study
原始语种摘要: Abstract(#br)Background(#br)This study compared the 2-year outcomes of patients with a manic/mixed episode of bipolar disorder taking olanzapine monotherapy or olanzapine in combination with other agents.(#br)Methods(#br)EMBLEM (European Mania in Bipolar Longitudinal Evaluation of Medication) is a 2-year, prospective, observational study of clinical and functional outcomes of bipolar patients with an index manic/mixed episode. The study consisted of two phases: acute (12weeks) and maintenance (follow-up over 2years). The longitudinal outcome measure was the Clinical Global Impression-Bipolar Disorder scale. Cox regression models compared outcomes of both therapy groups using intention-to-treat and switching medication analysis. Treatment-emergent...
全文获取路径: Elsevier  (合作)
影响因子:3.295 (2012)

  • bipolar 二极的
  • monotherapy 硫化物
  • mania 疯病
  • disorder 无序
  • observational 观察的
  • combination 聚形
  • acute 急尖的
  • treatment 处理
  • manic 铜镍锰合金
  • episode