Translating plasma eicosapentaenoic acid concentrations into erythrocyte percentages of eicosapentaenoic acid plus docosahexaenoic acid during treatment with icosapent ethyl
作者: William S. HarrisKristina H. Jackson
作者单位: 1Department of Internal Medicine, University of South Dakota, Sioux Falls, SD, USA
2OmegaQuant, LLC, Sioux Falls, SD, USA
刊名: Journal of Clinical Lipidology, 2019, Vol.13 (5), pp.771-777
来源数据库: Elsevier Journal
DOI: 10.1016/j.jacl.2019.07.001
关键词: Eicosapentaenoic acidDocosahexaenoic acidOmega-3 indexBiomarkerIcosapent ethyl
英文摘要: Background(#br)The Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT) study demonstrated that 4 g/d of eicosapentaenoic acid (EPA) ethyl esters (icosapent ethyl [IPE]) reduced risk for major cardiovascular events by 25% in statin-treated patients with residual hypertriglyceridemia. How this treatment affected red blood cell (RBC) EPA and docosahexaenoic acid (DHA) levels (ie, the Omega-3 Index [O3I]) was not reported, but effects on plasma EPA concentrations were reported.(#br)Objective(#br)The aim of the study was to estimate baseline and final O3I levels in REDUCE-IT.(#br)Methods(#br)First, deidentified data from our laboratory on RBC and plasma EPA and DHA from 2311 patients with similar lipid profiles as those in REDUCE-IT were used to generate a...
全文获取路径: Elsevier  (合作)
影响因子:2.741 (2012)

  • treatment 处理
  • concentrations 浓聚物
  • during 在的期间
  • plasma 深绿玉髓
  • ethyl 乙基
  • erythrocyte 红血球