Butylated hydroxyanisole alters rat 5α-reductase and 3α-hydroxysteroid dehydrogenase: Implications for influences of neurosteroidogenesis
作者: Jingjing GuoLili LiSongyi ZhouYing SuXiaoheng LiJianliang SunRen-Shan Ge
作者单位: 1Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
2Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
3Department of Anesthesia, Hangzhou Hospital Affiliated to Nanjing Medical University, Hangzhou First People’s Hospital, Hangzhou 310006, China
刊名: Neuroscience Letters, 2017, Vol.653 , pp.132-138
来源数据库: Elsevier Journal
DOI: 10.1016/j.neulet.2017.05.034
关键词: Butylated hydroxyanisoleNeurosteroid5α-reductase 13α-hydroxysteroid dehydrogenaseRetinol dehydrogenase 2
原始语种摘要: Abstract(#br)Butylated hydroxyanisole is a synthetic antioxidant. It may affect the function of the nerve system. The objective of the present study is to investigate the direct effects of butylated hydroxyanisole on rat brain neurosteroidogenic 5α-reductase 1 (SRD5A1), 3α-hydroxysteroid dehydrogenase (AKR1C14), and retinol dehydrogenase 2 (RDH2). Rat SRD5A1, AKR1C14, and RDH2 were cloned and expressed in COS1 cells, and the effects of butylated hydroxyanisole on these enzyme activities were measured. Butylated hydroxyanisole inhibited SRD5A1, AKR1C14, and RDH2 with IC 50 values of 4.731±0.079μM, 5.753±0.073μM, and over 100μM, respectively. Butylated...
全文获取路径: Elsevier  (合作)
影响因子:2.026 (2012)

  • butylated 丁基化的
  • dehydrogenase 脱氢酶
  • reductase 还原酶
  • SRD Shorted Rotating Diode
  • retinol 瑞叮醇
  • antioxidant 抗氧化剂
  • objective 接物镜
  • investigate 
  • binding 装订
  • values 价值观