Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats
作者: Chuan-sheng ZhaoKirsi PuurunenTimothy SchallertJuhani SiveniusJukka Jolkkonen
作者单位: 1Department of Neuroscience and Neurology, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
2Department of Psychology and Institute for Neuroscience, University of Texas, Austin, TX 78712, USA
3Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA
4Department of Neurology, University Hospital of Kuopio and Brain Research and Rehabilitation Center Neuron, Kuopio, Finland
刊名: Behavioural Brain Research, 2004, Vol.156 (1), pp.85-94
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbr.2004.05.011
关键词: AgingCerebral ischemiaFunctional recoveryMedication
原始语种摘要: Abstract(#br)The present study evaluated the effect of galanthamine, a selective competitive cholinesterase inhibitor, on histological and functional outcome after experimental stroke in rats. Cholinesterase inhibitors are commonly used as cognitive enhancers for dementia in aged people, including those who may sustain ischemic attacks. Young adult (5 months) and aged (24 months) rats were treated with saline or galanthamine at a dose of 2.5mg/kg (i.p., once a day). Drug treatment started 4 days before focal cortical photothrombosis (Rose Bengal, 20mg/kg) and continued for 21 days thereafter. Sensorimotor recovery was assessed by a new beam-walking test and spatial learning by the Morris water-maze over a 3-week follow-up period. Infarct volumes were...
全文获取路径: Elsevier  (合作)
影响因子:3.327 (2012)

  • galanthamine 雪花莲胺
  • ischemic 福尔克曼氏麻痹
  • adult 成体
  • cholinergic 胆碱能的
  • focal 焦点的
  • cortical 皮层的
  • outcome 效果
  • histological 组织的
  • functional 功能的
  • after 在之后