Mechanisms of Action of Eicosapentaenoic Acid in Bladder Cancer Cells In Vitro: Alterations in Mitochondrial Metabolism, Reactive Oxygen Species Generation and Apoptosis Induction
作者: Alison Colquhoun
作者单位: 1Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil
刊名: The Journal of Urology, 2008, Vol.181 (4), pp.1885-1893
来源数据库: Elsevier Journal
DOI: 10.1016/j.juro.2008.11.092
关键词: bladderbladder neoplasmsapoptosiseicosapentaenoic acidcardiolipins
原始语种摘要: Purpose(#br)Eicosapentaenoic acid has been tested in bladder cancer as a synergistic cytotoxic agent in the form of meglumine-eicosapentaenoic acid, although its mechanism of action is poorly understood in this cancer. The current study analyzed the mechanisms by which eicosapentaenoic acid alters T24/83 human bladder cancer metabolism in vitro.(#br)Materials and Methods(#br)T24/83 human bladder cancer cells were exposed to eicosapentaenoic acid for 6 to 24 hours in vitro and incorporation profiles were determined. Effects on membrane phospholipid incorporation, energy metabolism, mitochondrial activity, cell proliferation and apoptosis were analyzed. Reactive oxygen species and lipid peroxide production were also determined.(#br)Results(#br)Eicosapentaenoic acid was readily incorporated...
全文获取路径: Elsevier  (合作)
影响因子:3.696 (2012)

  • bladder 膀胱
  • intravesical 膀胱内的
  • epirubicin 表柔比星
  • meglumine 葡甲胺
  • cardiolipin 心脂质
  • cytotoxic 细胞毒素的
  • stimulating 促进
  • metabolism 代谢
  • phospholipid 磷脂
  • Cancer 巨蟹座