Identifying a therapeutic window in acute and subacute inflammatory sensory neuronopathies
作者: Jean-Christophe AntoineFlorence Robert-VarvatThierry MaisonobeAlain CréangeJérôme FranquesStéphane MathisEmilien DelmontThierry KuntzerJean-Pascal LefaucheurJean PougetKarine VialaClaude DesnuelleAndoni Echaniz-LagunaFrancesco RotoloJean-Philippe Camdessanché
作者单位: 1Centre de Référence Maladies Neuromusculaires Rares Rhône-Alpes, CHU de Saint-Etienne, France
2Université de Lyon, Saint-Etienne, France
3INSERM U1028, Centre des Neurosciences de Lyon, Lyon, France
4Centre de Référence Maladies Neuromusculaires Rares, Hôpital de la Salpêtrière, Paris, France
5Service de Neurologie, Hôpital Henri Mondor, Créteil, France
6Centre de Référence des Maladies Neuromusculaires et de la SLA, Hôpital de La Timone, Marseille, France
7Service de Neurologie, CHU de Poitiers, France
8Centre de Référence des Maladies Neuromusculaires et SLA, CHU de Nice, France
9Unité Nerf-Muscle, Service de Neurologie, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland
10Service de Neurologie, CHU de Strasbourg, France
刊名: Journal of the Neurological Sciences, 2016, Vol.361 , pp.187-191
来源数据库: Elsevier Journal
DOI: 10.1016/j.jns.2015.12.044
关键词: Sensory neuronopathySensory ganglionopathySensory action potentialsDiagnosisEvolution
原始语种摘要: Abstract(#br)Background(#br)Patients with inflammatory sensory neuronopathy (SNN) may benefit from immunomodulatory or immunosuppressant treatments if administered timely. Knowing the temporal profile of neuronal loss in dorsal root ganglia will help to ascertain whether a final diagnosis may be reached before the occurrence of irreversible neuronal injuries. Thus, we addressed the evolution of neuronal loss in SNN by using sensory nerve action potentials (SNAPs) as a surrogate marker of neuron degeneration.(#br)Methods(#br)Eighty-six patients with acute/subacute inflammatory SNN (paraneoplastic, associated with dysimmune diseases, or idiopathic) were retrospectively studied. The monthly SNAP reduction was determined and normalized with the lower limit of normal. Disability progression...
全文获取路径: Elsevier  (合作)
影响因子:2.243 (2012)

  • evolution 进化
  • subacute 亚急性的
  • sensory 传感
  • inflammatory 激怒的
  • reduction 减少
  • although 虽然
  • within 在以内
  • possible 可能的
  • stabilization 稳定
  • expressed 榨出的