Targeting CXCR7 improves the efficacy of breast cancer patients with tamoxifen therapy
作者: Mingang HaoXiaoling WengYingying WangXueqin SunTingting YanYu LiLidan HouXiangjun MengJianhua Wang
作者单位: 1Department of Biochemistry and Molecular & Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2Pathology Center, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China
3Department of Gastroenterology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
4Department of Breast Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
5Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
6Cancer Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China
7School of Medicine, Anhui University of Science & Technology, Huainan, Anhui 232000, China
刊名: Biochemical Pharmacology, 2018, Vol.147 , pp.128-140
来源数据库: Elsevier Journal
DOI: 10.1016/j.bcp.2017.11.013
关键词: Breast cancerCXCR7ERαTamoxifenERK1/2
英文摘要: Abstract(#br)Chemokine (C-X-C motif) receptor 7 (CXCR7) has been established to be involved in breast cancer (BCa) progression. However, the role of CXCR7 in different subtype of BCa still remains unclear. Here we note that CXCR7 expression is significantly amplified in Luminal type BCa tissues as compared with Her2 and TNBC types through data-mining in TCGA datasets, and its protein level positively correlates with ERα expression by staining of human BCa tissue. Interestingly, alteration of CXCR7 expression in Luminal type BCa cells is able to modulate the expression of ERα through ubiquitination at post-translational level. Additionally, overexpression of CXCR7 in these cells greatly induces 4-OHT insensitivity in vitro and is associated with earlier recurrence in patients with...
全文获取路径: Elsevier  (合作)
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影响因子:4.576 (2012)

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关键词翻译
关键词翻译
  • tamoxifen 他莫西芬
  • breast 胸部
  • efficacy 效验
  • cancer 癌症
  • therapy 治疗