Hydrogen sulfide ameliorates disorders in the parafacial respiratory group region of neonatal rats caused by prenatal cigarette smoke exposure via an antioxidative effect
作者: Xiang YanFusheng ZhaoSenfeng ZhangFang LeiWen WangYu Zheng
作者单位: 1Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041 Sichuan, PR China
2Department of Physiology, Mudanjiang Medical University, Mudanjiang, 157011 Heilongjiang, PR China
刊名: Environmental Toxicology and Pharmacology, 2019, Vol.68 , pp.80-90
来源数据库: Elsevier Journal
DOI: 10.1016/j.etap.2019.03.002
关键词: Hydrogen sulfidePrenatal cigarette smoke exposureParafacial respiratory groupSynapseAntioxidative effect
原始语种摘要: Abstract(#br)We previously found that hydrogen sulfide (H 2 S) ameliorated the dysfunction of central chemoreception caused by prenatal cigarette smoke exposure (CSE). In the present study, we further explored whether the parafacial respiratory group (pFRG) is involved in the protection of central chemoreception by H 2 S against prenatal CSE-induced injury. We found that NaHS, a donor of H 2 S, restored the expression of Phox2b, which was downregulated by prenatal CSE, in the pFRG region of neonatal rats. NaHS also relieved the prenatal CSE-induced excitatory synapse disturbance in the pFRG region of neonatal rats. Additionally, NaHS prevented the increase in the malondialdehyde level and suppression of antioxidase activity in the pFRG region of neonatal rats induced by prenatal CSE....
全文获取路径: Elsevier  (合作)
影响因子:2.005 (2012)

  • prenatal 产前的
  • neonatal 新生儿的
  • cigarette 香烟
  • effect 效应
  • exposure 暴露
  • region 地域
  • respiratory 呼吸过程
  • induced 感应的
  • smoke 灰云
  • sulfide 硫化物