Long non-coding RNA MALAT1 sponges microRNA-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating WNT1
作者: Hua FangHua-Feng LiMing-Hai HeJian-Yong YanMiao YangFang-Xiang ZhangRu-Rong WangQuan-Yun WangJian-Ping Zhang
作者单位: 1Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, 550002, PR China
2Department of Anesthesiology, Guizhou University People’s Hospital, Guiyang, 550002, PR China
3Department of Anesthesiology, West China Second University Hospital, Sichuan University, Chengdu, 610041, PR China
4Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, PR China
刊名: Brain Research Bulletin, 2019, Vol.152 , pp.1-10
来源数据库: Elsevier Journal
DOI: 10.1016/j.brainresbull.2019.06.004
关键词: Long non-coding RNA MALAT1MicroRNA-429WNT1DexmedetomidineHypoxic-ischemic brain damageHippocampal neuronsApoptosis
原始语种摘要: Abstract(#br)Hypoxic-ischemic brain damage (HIBD) is a common neurological disorder. Emerging reports reveal that long non-coding RNAs and microRNAs (miRs) are implicated in the progress of HIBD. In this study we tried to ascertain whether lncRNA MALAT1, with the involvement of miR-429 and WNT1, affects HIBD. Initially, a HIBD mouse model was established. Then, we treated HIBD mice with dexmedetomidine (DEX) and then up- or down-regulated the expression of MALAT1, miR-429 and WNT1 in HIBD mice and neurons. Meanwhile, brain injury and hippocampal neuronal apoptosis were evaluated. Moreover, the interaction among MALAT1, miR-429 and WNT1 in HIBD was investigated. MALAT1 and WNT1 were high-expressed in brain tissues of HIBD mice while miR-429 was low-expressed in brain tissues from HIBD...
全文获取路径: Elsevier  (合作)
影响因子:2.935 (2012)

  • coding 编码
  • brain 
  • regulate 控制
  • expression 表示
  • ischemic 福尔克曼氏麻痹
  • regulating 蝶的
  • expressed 榨出的
  • together 共同
  • observed 观察到的