Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension
作者: Paola StellaGiada BigattiLaura TizzoniCristina BarlassinaChiara LanzaniGiuseppe BianchiDaniele Cusi
作者单位: 1Division of Nephrology, Dialysis and Hypertension, Graduate School of Nephrology, University “Vita e Salute” San Raffaele, MilanItaly
2Graduate School of Nephrology, University of Milan, Milan, Italy
刊名: Journal of the American College of Cardiology, 2004, Vol.43 (2), pp.265-270
来源数据库: Elsevier Journal
DOI: 10.1016/j.jacc.2003.08.034
原始语种摘要: Abstract(#br)Objectives(#br)The aim of our study was to evaluate the relationship between aldosterone synthase gene polymorphism and cardiac dimensions in essential hypertension.(#br)Background(#br)Higher aldosterone synthase messenger ribonucleic acid levels in the human heart are accompanied by increased intracardiac aldosterone production, a phenomenon that is associated with cardiac fibrosis and hypertrophy. Recent evidence suggests that a polymorphism (−344C/T) in the promoter region of the aldosterone synthase gene is associated with increased constitutive aldosterone production.(#br)Methods(#br)Relationships between M-mode echocardiographic cardiac dimensions and aldosterone synthase −344C/T polymorphism were studied in 210 never-treated, middle-aged patients (age 41.6 ± 1.4 years)...
全文获取路径: Elsevier  (合作)
影响因子:14.086 (2012)

  • aldosterone 醛甾酮
  • hypertension 高血压
  • essential 本质的
  • polymorphism 多晶形
  • synthase 合酶
  • ventricular 室的
  • intracardiac 心内的
  • human 人的
  • hypertrophy 肥大
  • thickness 厚度