Lanosterol Synthase Genetic Variants, Endogenous Ouabain, and Both Acute and Chronic Kidney Injury
作者: Rossella IatrinoChiara LanzaniElena BignamiNunzia CasamassimaLorena CitterioRoberta MeroniLaura ZagatoAlberto ZangrilloOttavio AlfieriSimone FontanaLorenza MacrinaSimona Delli CarpiniElisabetta MessaggioElena BrioniGiacomo Dell’AntonioPaolo ManuntaJohn M. HamlynMarco Simonini
作者单位: 1Nephrology, Università Vita Salute San Raffaele, Milan, Italy
2Genomics of Renal Diseases and Hypertension Unit, Milan, Italy
3Anaesthesia and Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
4Università Vita Salute San Raffaele, Milan, Italy
5Cardiac Surgery Unit, Università Vita Salute San Raffaele, Milan, Italy
6IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele, Milan, Italy
7Department of Pathology, Università Vita Salute San Raffaele, Milan, Italy
8Physiology Department, School of Medicine, University of Maryland, Baltimore, MD
刊名: American Journal of Kidney Diseases, 2019, Vol.73 (4), pp.504-512
来源数据库: Elsevier Journal
DOI: 10.1053/j.ajkd.2018.10.012
关键词: Lanosterol synthase (LSS)Endogenous ouabain (EO)Renal damageAcute kidney injury (AKI)HypertensionRisk factorEstimated glomerular filtration rate (eGFR)Single-nucleotide polymorphism (SNP)Cardiovascular surgeryGenetic mutationBiomarkerRenal damage
英文摘要: Rationale & Objective(#br)Studies of humans and animals have suggested that endogenous ouabain (EO) and related genes are mediators of acute (AKI) and chronic kidney injury. We sought to examine the relationship among EO levels, genetic variants in lanosterol synthase (LSS; an enzyme that catalyzes synthesis of cholesterol, a precursor of EO), and both AKI and chronic kidney injury.(#br)Study Design(#br)2 prospective observational cohort studies and a cross-sectional study of kidney tissue.(#br)Setting & Participants(#br)(1) A prospective cohort study of patients undergoing cardiovascular surgery, (2) measurement of EO concentration in kidney tissue removed because of an adjacent tumor, and (3) a prospective cohort study of patients with newly diagnosed essential...
全文获取路径: Elsevier  (合作)
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影响因子:5.294 (2012)

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关键词翻译
关键词翻译
  • Kidney