Radiation-induced enteropathy: Molecular basis of pentoxifylline–vitamin E anti-fibrotic effect involved TGF-β 1 cascade inhibition
作者: Saad HamamaMarie Gilbert-SirieixMarie-Catherine VozeninSylvie Delanian
作者单位: 1Molecular Radiotherapy, Université Paris Sud XI, Le Kremlin Bicêtre, France
2Cellular and Molecular Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Salvatore Maugeri, Pavia, Italy
3Hôpital Saint-Louis, APHP, Paris, France
刊名: Radiotherapy and Oncology, 2012, Vol.105 (3), pp.305-312
来源数据库: Elsevier Journal
DOI: 10.1016/j.radonc.2012.08.023
关键词: Radiation-induced fibrosisRadiation enteropathyPentoxifyllineTocopherolTGF-β1Rho/ROCK
英文摘要: Abstract(#br)Background(#br)Radiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline–vitamin E has proven effective and safe in clinical trials in the treatment of fibrosis, while the molecular mechanism of its activity is yet unexplored.(#br)Methods(#br)Ten patients suffering from radiation-induced enteropathy were treated with pentoxifylline–vitamin E combination with SOMA score as the primary endpoint. In parallel, primary smooth muscle cells isolated from intestinal samples isolated from humans with radiation enteropathy were incubated with pentoxifylline, trolox (vit. E hydrophilic analogous) or their combination. Activation of the TGF-β1/Smad and Rho/ROCK pathways was subsequently investigated using Q-RT-PCR, gene reporter, Western-blot, ELISA and...
全文获取路径: Elsevier  (合作)
影响因子:4.52 (2012)

  • induced 感应的
  • enteropathy 肠病
  • fibrotic 纤维变性的
  • vitamin 维生素
  • cascade 小瀑布
  • pentoxifylline 己酮可可碱
  • inhibition 抑制
  • fibrosis 纤维化
  • effect 效应
  • involved 涉及