Association of VEGFA variants with altered VEGF secretion and type 2 diabetes: A case-control study
作者: Nejla SellamiLaila Ben LamineAmira TurkiSameh SarrayMohammed JailaniAbrar K. Al-AnsariMohamed GhorbelTouhami MahjoubWassim Y Almawi
作者单位: 1Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy of Monastir, University of Monastir, Tunisia
2Faculty of Science of Bizerte, University of Carthage, Tunisia
3Department of Laboratory Medicine, Northern Border University, Ara’ar, Saudi Arabia
4Faculty of Sciences, El-Manar University, Tunis, Tunisia
5College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
6School of Pharmacy, Lebanese American University, Byblos, Lebanon
刊名: Cytokine, 2018, Vol.106 , pp.29-34
来源数据库: Elsevier Journal
DOI: 10.1016/j.cyto.2018.03.003
关键词: GenotypeHaplotypesType 2 diabetesVascular endothelial growth factor
英文摘要: Abstract(#br)Background(#br)Vascular endothelial growth factor (VEGF) contributes to type 2 diabetes (T2DM) pathogenesis, and genetic variations in VEGFA gene were suggested to influence VEGF secretion and T2DM pathogenesis.(#br)Aim(#br)To evaluate the association of specific VEGFA variants with altered VEGF levels, and with T2DM among Tunisians.(#br)Subjects and methods(#br)A retrospective case-control study, performed on 815 T2DM patients, and 805 healthy controls. VEGF levels were measured by ELISA, genotyping of VEGFA variants was done by allelic exclusion method (real-time PCR).(#br)Results(#br)MAF of rs1570360, rs2010963, rs25648, rs833068, rs3025036, and rs3025039 were significantly different between T2DM cases and controls. Increased T2DM risk was associated with rs699947,...
全文获取路径: Elsevier  (合作)
影响因子:2.518 (2012)

  • diabetes 糖尿病
  • altered 改变的
  • secretion 分泌
  • Association 美国公共卫生协会
  • factor 因素
  • growth 生长
  • control 控制
  • endothelial 内皮的
  • study 学习