The estrogenic properties of Danggui Buxue Tang, a Chinese herbal decoction, are triggered predominantly by calycosin in MCF-7 cells
作者: Amy G.W. GongKei M. LauMiranda L. XuHuang Q. LinTina T.X. DongKen Y.Z. ZhengK.J. ZhaoKarl W.K. Tsim
作者单位: 1Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
2Department of Biology, Hanshan Normal University, Chaozhou, Guangdong 521041, China
3Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Road, Beijing 100050, China
刊名: Journal of Ethnopharmacology, 2016, Vol.189 , pp.81-89
来源数据库: Elsevier Journal
DOI: 10.1016/j.jep.2016.05.035
关键词: Danggui Buxue TangCalycosinChemical depletionPhosphorylationEstrogenic effects
原始语种摘要: Abstract(#br)Background(#br)D anggui B uxue T ang (DBT), a Chinese herbal decoction containing A stragali R adix (AR; roots of Astragalus memebranaceus (Fisch.) Bunge var. mongholicus (Bunge) Hsiao) and A ngelicae S inensis R adix (ASR; roots of Angelica sinensis Oliv.) at a weight ratio of 5:1, is used to improve menopausal syndromes in women. Several lines of evidence indicate that DBT has strong estrogenic property; however, the action mechanism of this herbal decoction is not known. Calycosin, a major flavonoid in AR, shares similar structure with β-estradiol, and thus which is hypothesized to be the key compound of DBT in responsible for such estrogenic properties.(#br)Aims(#br)We aimed to determine the role of calycosin in DBT in terms of its estrogenic functions by the creation of...
全文获取路径: Elsevier  (合作)
影响因子:2.755 (2012)

  • decoction 
  • estrogenic 动情的
  • herbal 草本的
  • triggered 触发的
  • extracts 摘记
  • properties 道具
  • flavonoid 黄酮类
  • Angelica 当归
  • hypothesize 假定
  • estradiol 雌二醇